The diagram below shows one theory of enzyme action Describe and explain what is happening at each stage. What enzyme theory does this represent?

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1 Answer
Jul 21, 2017

See below.

Explanation:

This illustrations depicts the color(magenta)"lock and key model"lock and key model of enzyme and substrate binding first proposed by Emile Fischer in his studies on enzymes in the nineteenth century.

ul"Illustration going from righ t to left"Illustration going from righ t to left−−−−−−−−−−−−−−−−−−−−−−−−−−−−

1. "Arrows point to the active sites"1.Arrows point to the active sites
"of the enzyme."of the enzyme.

2. "Substrates bind to the active"2.Substrates bind to the active
"sites of the enzyme -- [enzyme-substract] complex forms"sites of the enzyme -- [enzyme-substract] complex forms

3. "Enzyme-substracts turns into"3.Enzyme-substracts turns into
"enzyme-products ."enzyme-products .

4. "Products are released after catalyzed"4.Products are released after catalyzed
"reaction."reaction.

color(white)(aaaaaaaa)"Enzyme remains unchanged."aaaaaaaaEnzyme remains unchanged.

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This model proposes the idea that enzymes are like locks and substrates are the keys to that lock. The key has to match up perfectly to the grooves of the lock, or in other words, be color(magenta)"complementary"complementary to them.

https://artofbiochemistry.wordpress.com/2013/03/02/1250/https://artofbiochemistry.wordpress.com/2013/03/02/1250/

This model, however, posed many problems to scientists because such an color(magenta)"enzyme-substrate complex"enzyme-substrate complex would lead to poor catalysis. The reason being is after binding, the enzyme-substrate complex, [ES] would become more stable than the substrate itself, [S], and thus, be lower in free energy, "G"G. And because [ES] is lower in free energy, the activation energy, symboled as Delta"G"^‡"ΔG, would increase instead of decrease.

color(white)(.......)color(red)[Delta"G"^‡"catalyzed" >DeltaG^‡"uncatalyzed"

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In later studies, biochemists came up with a better model to explain how enzymes and substrates bind - color(magenta)["the induced fit model".