Which of the four bases is present in a higher percentage in an eukaryotic telomere?

1 Answer
Nov 28, 2017

T TAGCG is repeated many times in human telomeres.

On the lagging strand of parent DNA in DNA replication, there is a length unreplicated because it's "too short" to make another Okazaki fragment.

As we know, replication on the lagging strand is dictated by Okazaki fragment polymerization by RNA polymerase in the 5' to 3' direction.

A good inference based on these interactions is the fact that chromosomes shorten as a function of the number of times replicated""^1.

References:

  1. Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., . . . Harley, C. B. (1992). Telomere length predicts replicative capacity of human fibroblasts. Proceedings of the National Academy of Sciences, 89(21), 10114-10118. doi:10.1073/pnas.89.21.10114