On a cyclohexyl ring which substituent would cause the greatest transannular interaction: #Me#; #Pr^(i)#; #Bu^t#?

1 Answer
anor277
Jun 1, 2017

Well, which substituent is most sterically bulky?

Explanation:

Clearly, #Bu^t# is the most sterically bulky, and axial substitution would result in significant trans-annular interaction. Can you make a model so that you appreciate this interaction?

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