What would occur if we used wet solvent in a Grignard reaction?
1 Answer
Reduced yield.....
Explanation:
The Grignard reagent is a powerful nucleophile, and a powerful base. The use of wet ether or wet THF would result in difficulty in forming the Grignard reagent....
Sometimes we form the Grignard reagent and quench it with
As a practical tip, when you start out making Grignard reagents, you often go to absurd lengths in drying your solvents. Now Grignards are water-sensitive, but they are a bit more robust than you might think... I used to make molar quantities of Grignards with diethyl ether that had dried over molecular sieves, and used straight out of the bottle.
