We define a new variable #u=1+4x^2#. Now, #(du)/dx=8x#. We then divide both sides by #8x# and multiply both sides by #dx# (an abuse of notation) to get #dx=(du)/(8x)#.
Now, let's look at our original integral: #int\ x/(1+4x^2)^2\ dx#. We can substitute the above variables to get #int\ x/(8xu^2)\ du=int\ 1/(8u^2)\ du#. Remember that you can always factor a constant out of the integral: #1/8int\ 1/(u^2)\ du#. We know that #1/u^2# is simply equal to #u^-2#: #1/8int\ u^-2\ du#. We apply the rule that #int\ x^a\ dx=x^(a+1)/(a+1)+C# for a constant #a# on this integral to get #1/8(u^(-2+1)/(-2+1)+C)=1/8(u^-1/-1+C)=-1/(8u)+1/8C#.
Since #C# is just an arbitrary constant, #1/8C# is also just an arbitrary constant. We can just replace #1/8C# by #C# to get #1/8(u^-1/-1+C)=-1/(8u)+C#.
However, we want our answer to be in terms of #x#. We said before that #u=1+4x^2#. We just need to substitute this in to get our final answer of #-1/(8+32x^2)+C#.