How does aspirin help to reduce clotting? Does it reduce the red blood count, reduce platelet aggregation, reduce the platelet count, bind to fibrin, or inhibit thrombin?
Reduce Platelet Aggregation
Thromboxane A2 (TXA2) is a chemical that is produced from cell membrane Phospholipid, and increases platelet aggregation inside blood vessels.
Aspirin reduces the TXA2 production from membrane phospholipid by blocking COX-1 enzyme.
We have seen that Thromboxane A2 (TXA2) increases platelet aggregation. And aspirin decreases the production of TXA2. As a result aspirin decreases platelet aggregation and thus help to reduce clotting.