Question

How does chirality effect nmr?

Answer 1

A left handed stereoisomer would give precisely the same NMR spectrum as the right handed stereoisomer in the standard experiment. How do I know this?

Explanation:

Because enantiotopic nuclei on the same molecule give the same NMR signal in the normal experiment. If a chiral NMR solvent is used (these do exist), the enantiotopic nuclei should give rise to separate absorptions.

Note that enantiotopic nuclei are those nuclei that can be interchanged ONLY by an improper axis of rotation (i.e. a mirror plane).