How does the watson-crick model of dna relate to chargaff’s rule?

1 Answer
Aug 30, 2015

The structure of DNA requires that adenine always bonds with thymine, and cytosine always bonds with guanine.


The nitrogenous bases of DNA include the purines adenine (A) and guanine (G), and the pyrimidines thymine (T) and cytosine (C). Chargaff's rule states that there is always a 1:1 ratio of purines to pyrimidines in DNA. More specifically, the #A = #T and the #G = #C.

This is reflected in the molecular structure of the Watson-Crick model of DNA, where the two strands of DNA are held together by hydrogen bonding between nitrogenous bases. Their model shows how A always bonds with T and G always bonds with C.