Question

The Ames test uses bacteria to test for what?

Answer 1

The Ames test is a widely employed method that uses bacteria to test whether a given chemical can cause mutations in the DNA of test organisms.

Explanation:

The Ames test uses several strains of the bacterium Salmonella tyhimurium that carry mutations in genes involved in histidine synthesis. The method tests the capability of the tested substance in creating mutations that result in a return to a prototypic state so that the cells can grow on a histidine free medium.

This test is a biological assay to assess the mutagenic potential of chemical compounds. It serves as a quick and convenient assay to estimate the carcinogenic potential of a compound. A positive test indicates that the chemical is mutagenic and therefore may act as a carcinogen, as cancer is often linked to mutation.

The Ames test is also used as one of the initial screens for potential drugs to weed out possible carcinogens.