Question

The drug Seconal, a powerful sedative, influences which of the following ions to accumulate within neurons? A. chloride B. calcium C. sodium D. potassium

Answer 1

`A`.

Explanation:

Seconal or SECOBARBITAL is a barbiturate group of drug,which is a potent sedative and well known for their abuse liability.

They binds to the specific GABA receptor subunits and opens the `Cl^(-)` channels for longer than the normal time,which results in prolonged `Cl^(-)` current through the synapse resulting in hyperpolarization of the cells,so due to lack of depolarization,neurons can't fire action potentials and the result is drowsiness.