What is required for a chemical reaction to occur?
C => Proper Kinetic Concentration of Reactants. That is, reacting substances must be able to find one another.
E => Effective Collisions between reacting substances such that bonding can occur. This translates into 'orientation' of collision between particles is a significant factor in formation of a chemical bond.
N => Naturally reactive substances. Reactants in a chemical reaction must have a natural tendency to bond. Judicial choice of reacting species is vital to formation of specified products.
T => Transition Energy (Activation Energy) that is sufficient to afford the greatest probability of forming products. Substances with sufficient energy will interact a sufficient number of times to effect formation of bonds and production of products.