Question

What problem does a cell have when it generates large amounts of ATP from glycolysis?

Answer 1

Large amounts of ATP signals the cell that it should not proceed with glycolysis.

Explanation:

Why? Why would high levels of ATP inhibit glycolysis? Think about it. Glycolysis produces ATP when the body needs it most. When you have enough of ATP, the body is essentially producing more of something it no longer needs.

In the conversion of Fructose 6 phosphate to Fructose 1, 6 Bisphosphate, high levels of ATP, and citrate allosterically inhibit PFK-1 (phosphofructokinase-1). This is important in the regulation of glycolysis.

Instead of burning glucose for energy, the extra glucose is used to make stored fat and glycogen which occurs in the liver. The liver is a major contributor to our metabolism in maintaining a perfect balance in our body.