Why does chelation of calcium prevent blood clotting?

1 Answer
Nov 7, 2017

#Ca^(2+)# acts a a co-factor for many enzymes. Think of it as a car key: without it the engine won't start.


Blood clotting is a complex process, involving a cascade of reactions.

Somewhere in this chain, activated platelets will have an increased level of #Ca^(2+)# in their cytosol. This Calcium acts as the starter key for the enzyme Protein Kinase C. Take the #Ca^(2+)# away, e.g. with EDTA, and the protein won't start....