What family of proteins do nuclear lamins belong to?
1 Answer
Nuclear lamins belong to intermediate filament (IF) family of proteins. They provide structural function and transcriptional regulation in the cell nucleus.
Explanation:
Lamins are the major architectural proteins and line the inside of the nuclear membrane. They form a platform for the binding of proteins and chromatin and confer mechanical stability.
Lamins polymerise into fibres forming a protein mesh work. They have a tripartite structure with two globular head and tail.
They are involved in the disassembling and reforming of the nuclear envelope during mitosis, as well as the positioning of nuclear pores.
They are also involved in a wide range of nuclear functions including :-
Higher order genome organisation ,
Chromatin regulation
Transcription
DNA replication
DNA repair.
Mutations in lamins cause a large number of diverse human diseases collectively known as laminopathies.
