Where do B cells and T cells mature?
1 Answer
Mammalian B cells mature in the bone marrow, which is the core of most bones. T cells mature in the thymus from thymocytes .
Explanation:
T cells
T cells are a type of lymphocyte that play a central role in the cell mediated immunity.
All T cells originate from haematopoietic stem cells in the bone marrow. Haematopoietic progenitors from haematopoietic stem cells populate the thymus and expand by cell division to generate a large population of immature thymocytes.
About 98% of thymocytes die during the development process in the thymus by failing either the positive selection or the negative selection. The 2% that survive , leave the thymus to become mature immuno competent cells.
B cells
B cells function in the humoral immunity component of the adaptive immune system by secreting antibodies.
B cells develop from haematopoietic stem cells that originate from bone marrow. B cells undergo two types of selection while developing in the bone marrow to ensure proper development.
To complete development immature B cells migrate from the bone marrow to the spleen as well as pass through two transitional stages.
