Question #6add2

1 Answer
Dec 8, 2016

Charged amino acids are often found deep in proteins because they make up the protein's active site, where they contribute to binding specificity and catalysis.


As a general rule (many exceptions), enzyme active sites are positioned deep inside the centres of the proteins. Charged amino acids in the active sites are often involved in interacting correctly with the substrate in the active pocket to ensure that the molecule is positioned the right way.

They are also important in distorting and stressing certain partial charges in the substrate (sometimes they go as far as bond to or lend an electron to the substrate) so that it enters a transition state and gets converted into product.