# What is allosteric inhibitor?

For example: $\text{ATP}$ act as allosteric inhibitor of enzyme pyruvate kinase during glycolysis. Pyruvate kinase speeds up the last step of glycolysis by transferring the phosphate from phosphoenol pyruvate$\left(\text{PEP}\right)$ to $\text{ADP}$ to form $\text{ATP}$. The formed $\text{ATP}$ itself distorts the shape of the active site by binding to the allosteric site of pyruvate kinase. Hence it actually act as allosteric inhibitor in this case.