A mutation occurred in the middle of a DNA sequence from the coding strand as shown by the partial sequence below. Determine the molecular impact of this mutation and explain the possible effects resulting from this mutation. Please be specific on this?

Normal DNA sequence: -3’…TTC GTC GCT…5’

Mutated DNA sequence: -3’…TTC ATC GCT…5’

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1 Answer
Al E.
Nov 21, 2017

There is no immediate effect in transcription.

However, when the mRNA is translated, translation will be terminated early as the anticodon of the #UAG# codon transcribed in the mutated mRNA corresponds to a release factor that separates the ribosomal subunits.

Implications will obviously be a dysfunctional protein because not all of its ended amino acid sequences will be synthesized in translation.

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