How can I make acetophenone from benzene?

1 Answer
il maestro
Feb 28, 2018

Friedel-Crafts acylation

Explanation:

Benzene is reacted with acetyl chloride in the presence of a Lewis acid such as AlCl3.

#AlCl_3# + #H_3C-COCl## ->##AlCl_4^-# + #H_3C-CO^+#
#C_6H_6# + #H_3C-CO^+##->##C_6H_6^+#-#COCH_3#
#C_6H_6^+##-COCH_3#+ #AlCl_4^-##->##C_6H_5-COCH_3#+#HCl#+#AlCl_3#

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