How do citrate, AMP, and ATP regulate the cellular respiration?

1 Answer
Carlo Remillion
Feb 11, 2016

They act as allosteric effectors of the enzymes involved in the TCA cycle primarily, the pyruvate dehydrogenase complex and citrate synthase

Explanation:

Increase in the concentration of AMP in the cell stimulates the pyruvate dehydrogenase complex to convert pyruvate to acetyl CoA so that in can enter the TCA cycle to produce more ATP. However if more energy in the form of ATP is available, ATP will inhibit the conversion of pyruvate to acetyl CoA.

On the other hand, increase in citrate concentration in the cell inhibits citrate synthase which condensed acetyl CoA and oxaloacetate to produce citrate.

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