First, multiply the terms in the top part of the fraction:
#(-((piR^2)/16)(R/4))/((16piR^3 - pitR^2)/16) =>#
#((-piR^2 * R)/(16 * 4))/((16piR^3 - pitR^2)/16) =>#
#((-piR^3)/64)/((16piR^3 - pitR^2)/16)#
Now, we can use this rule for dividing fractions to simplify the expression:
#(color(red)(a)/color(blue)(b))/(color(green)(c)/color(purple)(d)) = (color(red)(a) xx color(purple)(d))/(color(blue)(b) xx color(green)(c))#
#(color(red)(-piR^3)/color(blue)(64))/(color(green)(16piR^3 - pitR^2)/color(purple)(16)) =>#
#(color(red)(-piR^3) xx color(purple)(16))/(color(blue)(64) xx color(green)((16piR^3 - pitR^2))) =>#
#(color(red)(-piR^3) xx color(blue)(cancel(color(purple)(16))))/(color(purple)(cancel(color(blue)(64)))4 xx color(green)((16piR^3 - pitR^2))) =>#
#color(red)(-piR^3)/(4color(green)((16piR^3 - pitR^2))) =>#
#color(red)(-piR^3)/(color(green)((64piR^3 - 4pitR^2))) =>#
#color(red)(piR^2 * -R)/((piR^2 * 64R) - (piR^2 * 4t)) =>#
#color(red)(piR^2 * -R)/(piR^2(64R - 4t)) =>#
#color(red)(color(black)(cancel(color(red)(piR^2))) * -R)/(color(red)(cancel(color(black)(piR^2)))(64R - 4t)) =>#
#(-R)/(64R - 4t) =>#
#(-1)/-1 xx (-R)/(64R - 4t) =>#
#(-1 xx -R)/(-1(64R - 4t)) =>#
#R/(-64R + 4t) =>#
#R/(4t - 64R) =>#