# How would you explain how independent assortment, crossing over, and random fertilization contribute to genetic variation?

##### 1 Answer

Each factor contributes to a different combination of alleles in a haploid gamete.

#### Explanation:

During Meiosis I, there are two ways each homologous pairs of chromosomes can line up ( I I' ) & ( I' I ) - we can calculate the possible number of random combinations of chromosomes in each gamete (ie. sperm/egg) using the equation:

number of possible combinations =

where n is the number of chromosomes in the system.

Humans have 23 chromosomes so this gives rise to 8,388,608 genetically unique gametes through independent assortment alone

Random fertilization refers to the fact that if two individuals mate, and each is capable of producing over 8million potential gametes, the random chance of any one sperm and egg coming together is a product of these two probabilities - some 70 trillion different combinations of chromosomes in a potential offspring.

*think about that for a second*

Crossing over occurs during tetrad formation of Metaphase I of meiosis; when portions of the homologous pairs get exchanged, it results in the sister chromatids involved being recombined and genetically distinct from the other sister chromatid - this can happen more than once and can happen at random loci (locations) on the chromosome.

Because crossing over can give rise to an additional unique combination of alleles, each occurrence would effectively double the number of genetically unique gametes - and because crossovers occur randomly this means that number earlier (70 trillion) doesn't even begin to describe the potential variation in offspring that can exist given the three concepts listed.