What is the pathway a uric acid molecule takes from a glomerulus to the urethra?
Uric acid molecules appear in the glomerular filtrate by ultrafiltration, but only 10% of the filtered load gets excreted. The rest is absorbed back into the blood through the tubules.
Here are the major signposts along the way.
Through the nephron
The major landmarks are passed as the molecule moves through the nephron.
Glomerulus → Bowman's capsule → proximal convoluted tubule → descending loop of Henle → ascending loop of Henle → distal convoluted tubule → collecting duct
After the nephron
Hundreds of collecting ducts feed into a minor calyx (cup)
Two or three minor calyces converge to form a major calyx.
These feed through the renal pelvis into the ureter
Collecting duct → minor calyx → major calyx → renal pelvis → ureter
The final path
The ureter feeds into the bladder and urethra.
Ureter → bladder → urethra → OUT!