Question

What is the product of glucuronidation of salicylic acid?

Answer 1

There are two products: salicylic acid acyl-β-D-glucuronide and salicylic acid phenolic-D-glucuronide.

Explanation:

The structure of salicylic acid is

Two of the pathways for metabolism of salicylic acid involve reaction with glucuronic acid:

Glucuronidation converts the salicylic acid into water-soluble compounds that can be more easily excreted in the urine and the bile.

In one pathway, the `"COOH"` group of salicylic acid reacts with the anomeric `"OH"` group of glucuronic acid to form an ester, salicylic acid acyl-D-glucuronide.

In the second pathway, the phenolic `"OH"` group of salicylic acid reacts with the anomeric `"OH"` group of glucuronic acid to form a glycoside, salicylic acid phenolic-D-glucuronide.