What kind of connections can you make between the Louisiana Purchase and Indian Removal to lands west of the Mississippi River?
Thinking as if you had no knowledge of the matter, you can infer that Americans wanted to explore and inhabit the land that was known as the Louisiana Territory, even if they had to move Native Americans westwards to do so.
After the United States bought Louisiana Territory from France in the 18th century, they wanted to explore and search the area. They had goals of finding new species of animals and plants, documenting things never seen before, and more.
An expedition known as the Lewis and Clark Expedition, led by Meriwether Lewis and William Clark, took place as a way to discover the newly acquired land.
After some time, the United States passed the Indian Removal Act. This act forced Native Americans to move even further away from their home, especially in Georgia, because they speculated the existence of gold.
Above all, the main reason there was Indian removal was for the exploration of the Louisiana Purchase.