Where in the body are hemopoietic stem cells found?
1 Answer
Hematopoietic Stem Cells (HSC) are derived from mesoderm and located in the red bone marrow, which is contained in the core of most bones.
Explanation:
HSC are found in the bone marrow of adults, especially in the pelvis, femur and sternum. They are also found in the umbilical cord blood and in small numbers in peripheral blood.
In mammalian embryology, the first definitive HSC are detected in the aorta-gonad mesonephrons, and then massively expanded in the fetal liver prior to colonising the none marrow before birth.
HSC have a higher potential than other immature blood cells to pass the bone marrow barriers, and thus may travel in the blood from the bone marrow in one bone to another bone. If they settle in the thymus to they may develop into T-cells. In the case of foetuses and other extra medullary hematopoiesis, HSC may also settle in the liver or spleen and develop further.
HSC are the stem cells that give rise to all the other blood cells through the process of hematopoiesis. The haematopoietic tissue contains cells with long term and short term regeneration capacities and committed multi potent, oligopotent, and uni potent progenitors.
