Why is DNA synthesis expected to be more complex in eukaryotes than in bacteria?

1 Answer
Jun 21, 2018

Eukaryotes have multiple replication forks, histones


Eukaryotes have multiple replication forks and therefore if replication occurs, various precautions need to be set in place to prevent unwinding of the DNA strand in multiple sites in a single replication cycle.

DNA in eukaryotes is packeged around histones to form chromatin. Before replication can occur, DNA needs to first be unwound around histones.

There are various other reasons for this, such as the presence of telomeres, high number of polymerase.

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