Question

Question #16b4b

Answer 1

yes eventually, but before that it causes the DNA to loose purines

Explanation:

DNA under low pH causes the breakage between the purine bases and the sugar backbone bond of the DNA, causing the DNA to be depurinated. degree of depurination depends on factors like pH, incubation period and the structure of DNA (amount of A-T and C-G bonds)

once the depurination occurs the purines are removed from DNA and making DNA structure unstable resulting denatration of DNA

NOTE:
to denature the DNA helix high pH conditions are used which is exploited in the alkaline lysis plasmid isolation method. as the `OH^-` is released in basic solution the `H^+` from the bases is taken by `OH^-`. as the `H^+` is not present over the nitrogen bases it makes DNA to denature.