How do you go from chloroform to methylacetylene in as few steps as possible?
2 Answers
Nov 1, 2015
pl refer the conversion
Explanation:
i didnt come up with this answer. i found this over the internet.
here's the link and all credit goes to the person who wrote this. no copying intended =)
Nov 2, 2015
There's a simpler and much cheaper way, if we're going completely theoretical.
- Just put chloroform into solution with 1 equivalent of ethyllithium (the lithium is a fantastic lewis acid) to extend the alkyl chain. You can find ethyllithium in an ethyllithium / benzene solution.
- Two equivalents of tert-butoxide in tert-butanol solvent and raise the temperature to promote two instances of
#E2# (bulky nucleophile is terrible at substitution). The alcohol solvent ends up cleaning up any remaining ethyllithium by protonating the ethyl anion
Or, here's a less experimental way of doing it.
- React with 1 equivalent of magnesium in dry ether to make a chlorogrignard reagent, a good nucleophile
- React that with an equivalent of ethyl chloride, a good electrophile. Then the water cleans up any remaining
#"MgCl"^(+)# and turns it into#"Mg"("OH")_2(s)# - Two equivalents of tert-butoxide in tert-butanol solvent and raise the temperature to promote two instances of
#E2# (bulky nucleophile is terrible at substitution).