We need to apply the chain rule twice.
Recall that the chain rule states, if we have some function f(g(x)), the derivative of f with respect to x is equal to the derivative of f with respect to g, multiplied by the derivative of g with respect to x.
So in this case, the derivative dy/dx will equal the derivative of sin(tan 2x) with respect to tan 2x (basically, treat tan 2x as a whole variable) times the derivative of tan 2x with respect to x.
Derivative of sin is just cos:
dy/dx = cos(tan 2x) * d/dx[tan 2x]
Derivative of tan is sec^2. However, we need to apply the chain rule again, meaning this time we will just pull the derivative of 2x out. (which is just 2)
dy/dx = cos(tan 2x) * sec^2(2x) * 2