Question

How does a deletion mutation differ from a substitution mutation?

Answer 1

Deletion mutation is deletion of a base from the genetic sequence, which changes the codon reading frame beyond the point of mutation.
Substitution mutation involves replacement of a base (e.g. one purine) by another base (either purine or pyrimidine).

Explanation:

Deletion mutation will lead to frameshift : Substitution mutation will not.

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