Does the leading strand require DNA ligase?

1 Answer
Saliha
Feb 15, 2018

No!

Explanation:

The purpose of #"DNA ligase"# is to join the okazaki fragments that are manufactured at lagging strand of replication fork. While at leading strand, the nucleotides are added continuously to the growing #3^'# end. So it doesn't have any okazaki fragments, hence it doesn't need #"DNA ligase"# .

https://yourmomislike.wordpress.com/2012/12/01/your-mom-is-like-an-okazaki-fragment/

Hope it helps!

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