How can prions be killed?
Prions are not alive, so they can not be killed but they can be deactivated.
Prions are highly resistant to disinfectants, heat, ultraviolet radiation, ionizing radiation and formalin.
Prions can be destroyed through incineration providing the incinerator can maintain a temperature of 900 F for four hours. In an autoclave, prions can be deactivated by using a temperature of 270 F at 21 psi for 90 minutes.
If the infectious material is in a solution of sodium hydroxide, deactivation will occur after one hour at 250 F and 21 psi.