Prophylactic antibiotics given* | Entire cohort (n=663) | Gestation under 10 weeks (n=642) | Gestation 10 weeks – 11 weeks and 6 days (n=21) |

Yes | 599 (90.3%) | 581 (90.5%) | 18 (85.7%) |

No | 44 (6.6%) | 42 (6.5%) | 2 (9.5%) |

Unknown | 20 (3.0%) | 19 (3.0%) | 1 (4.8%) |

Prophylactic antibiotics used* | Given antibiotics (n=599) | Gestation under 10 weeks given antibiotics (n=581) | Gestation 10 weeks – 11 weeks and 6 days given antibiotics (n=18) |

Took all | 383 (63.9%) | 369 (63.5%) | 14 (77.8%) |

Took some | 53 (8.8%) | 52 (9.0%) | 1 (5.6%) |

Took none | 97 (16.2%) | 95 (16.4%) | 2 (11.1%) |

Unknown | 66 (11.0%) | 65 (11.2%) | 1 (5.6%) |

Antiemetic use† | Entire cohort (n=663) | Gestation under 10 weeks (n=642) | Gestation 10 weeks – 11 weeks and 6 days (n=21) |

Yes | 611 (92.2%) | 591 (92.1%) | 20 (95.2%) |

No | 32 (4.8%) | 31 (4.8%) | 1 (4.8%) |

Unknown | 20 (3.0%) | 20 (3.1%) | 0 |

Number of doses of antiemetic used, of those answering ‘Yes’ to antiemetic use† | Cohort reporting number of doses (n=608, 3 did not report number of doses used) | Gestation under 10 weeks reporting number of doses (n=588) | Gestation 10 weeks – 11 weeks and 6 days reporting number of doses (n=20) |

Median | 2 | 2 | 2 |

Mean | 2.1 | 2.1 | 2.7 |

SD | 0.9 | 0.9 | 1.1 |

*Antibiotics given were a 7-day course of oral doxycycline 100 mg twice daily. ‘Took all’ means completed the whole course, ‘Took some’ means they used at least one dose but did not complete the full course, ‘Took none’ means they did not use any doses’.

†All patients were provided with five doses of cyclizine 50 mg and directed to use one tablet before mifepristone, one before misoprostol, and the remainder as required.