How do you simplify (2+-8) / (-4+6)?

The denominator of this fraction is $- 4 + 6 = 2$
We can divide both terms of the numerator, and also the denominator, by $2$:
$\frac{\cancel{2} \cdot 1 \pm \cancel{2} \cdot 4}{\cancel{2}} = 1 \pm 4$
So the solution is either $5 \mathmr{and} - 3$