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# How does the respiratory system work with the muscular system? Would it be possible for respiration to occur without muscle function?

Feb 27, 2016

In this way, the respiratory system is dependent upon the muscular system. However, the muscular system requires the oxygen that is brought in from the respiratory system to act as the final electron acceptor in oxidative phosphorylation. Without ${O}_{2}$, the muscles would be unable to generate enough ATP to continue contracting and functioning properly in general.