In IgG, what is the antigen binding site formed by?

1 Answer
Jonathan · Stefan V.
Feb 28, 2018

Great question but hard to answer. The correct response is the genetic sequence for the VDJ recombination site for the specific B cell.

Explanation:

Each B cell that makes a single and specific antibody (IgG, IgE - etc.) has to be told what the protein will look like to create the greatest affinity to that antigen. DNA #-># RNA #-># Protein - so, if that one B cell needs to make a specific antibody it has to have the unique gene to do so.

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