Question

What are the causes of vaculated lymphocytes? Is this an inherited disorders?

Answer 1

Metabolic disorders sometimes cause accumulation of metabolic by products , which are manifested as cytoplasmic vacuoles in lymphocytes.

Explanation:

Vacuolated lymphocytes may be caused by or feature the following :
- Alpha mannosidase deficiency
- ceroid lipofuscinosis, neuronal 1, infantile.
- Fucosidosis
- Galactosialidosis
- Glycogenosis type 2
- Mucolipidosis II alpha / beta
- Mucopolysaccharidosis type IV B
- Neuronal ceroid lipofuscinosis 3 , juvenile
- Salla disease
- Sphingomyelinase deficiency.

Such abnormal cytoplasmic vacuolationof lymphocytes can be identifiable as routine blood film examination.

Lymphocytes vacuolation occurs in a wide spectrum of inherited metabolic disorders.