What are the downsides of antacids?

1 Answer
Apr 11, 2015

People take antacids to neutralize the acids in the stomach.

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Numerous downsides are associated with the excessive and prolonged use of antacids.

Many of the problems are related to increased stomach pH:

  • An imbalance of gut flora (overgrowth of H. pylori leads to ulcers).
  • Suppressed activity of the dietary enzyme pepsin
  • Impaired absorption of
    o Vitamin B-12 (anemia)
    o Calcium and phosphorus (osteoporosis)
  • Diarrhea or constipation
  • Erosion of esophagus

Specific components have their own effects.

Sodium Hydrogen Carbonate

  • High sodium content (high blood pressure)
  • Systemic alkalosis — excess base in body fluids
  • Reduced iron absorption (anemia)

Calcium Carbonate

  • Acid rebound —the stomach produces even more acid
  • Reduced iron absorption
  • Bloating, cramps, and kidney stones
  • Systemic alkalosis

Magnesium Hydroxide

  • Interference with various enzymes (renal failure)
  • Lowered blood pressure

Aluminium Hydroxide

  • Altered absorption of certain drugs.
  • Potential brain damage