What is adenosyl methionine tosylate disulfate?

1 Answer
Sep 9, 2016


#S#-Adenosylmethionine (SAMe, pronounced "Sammy") is a common methyl donor and a cofactor for enzyme-catalyzed methylations.


It consists of adenosine and methionine joined by a sulfonium ion linkage.


It is sold as a prescription drug to help fight depression, liver disease, and the pain of osteoarthritis.

SAMe is highly hygroscopic, so it is converted into stable salts of sulfuric and p-toluenesulfonic acids.


Thus, every true 200 mg SAMe tablet contains 200 mg of SAMe and 200 mg of the sulfate and p-toluenesulfonate (tosylate) ions.