# What is the phosphodiester bond and how is it drawn?

Apr 17, 2018

See Below

#### Explanation:

Nucleotide Monophosphates, NMPs, are nucleosides that have 1 phosphate group. Here is GMP.

All simple nucleotides have this phosphoester bond.

When one nucleotide makes a linkage with another nucleotide, the phosphate group (which already has 1 ester bond) makes a 2nd ester bond. This becomes a phosphodiester bond.

In the picture below, the phosphate group has one ester bond to the nucleotide below, and one ester bond to the nucleotide above. This is the phosphodiester bond.