Why was bretylium tosylate discontinued?

1 Answer
Apr 22, 2016


The American Heart Association removed bretylium tosylate from their guidelines because of "ongoing supply problems".


The manufacturers could not provide a reliable supply of the drug.

The structure of bretylium tosylate [(o-bromobenzyl)ethyldimethylammonium
p-toluenesulfonate] is


You can probably imagine the difficulty of carrying out an electrophilic aromatic substitution that puts two bulky groups next to each other on a benzene ring.

If you can devise an efficient synthesis of bretylium tosylate for the pharmaceutical companies, you will become a rich person.