How can you determine E and Z isomers in a molecule?
Priority is assigned to substituents about the double bond (remember absolute configuration?). When both of the highest priority groups are on the same side, it is
For instance, consider pladienolide B,
I highlighted the bond in consideration so you wouldn't be playing Where's Waldo?!
The ring system to the right would be considered highest priority per the normal rules, and the
They are on different sides. Hence, this is an
For fun, it has approximately 256 stereoisomers it could be, and here is its enantiomer,
where all of its chirality centers (not the one on the