# What is the diference between the most common two-dimensional NMR techniques: COSY and HETCOR?

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In COSY, the proton spectra are plotted along each axis, while in HETCOR the proton spectrum is on one axis and the $\text{^13"C}$ spectrum is on the other axis.

#### Explanation:

COSY$\text{CO}$rrelation $\text{S}$pectroscop$\text{Y}$
(you may also see it written as H,H-COSY)

In COSY, both axes correspond to $\text{^1"H}$ NMR spectra.

The off-diagonal peaks show which protons are coupled to each other.

The COSY spectrum of ethyl but-2-enoate

(from www.chem.ucalgary.ca)

is

(from www.chem.ucalgary.ca)

For example, peak A indicates a coupling between the $\text{H}$ at 6.9 ppm and the $\text{H}$ at 1.8 ppm.

This shows that the ${\text{CH}}_{3}$ group is coupled to the adjacent $\text{H}$ on the alkene.

HETCOR$\text{HET}$eronuclear $\text{COR}$relation Spectroscopy

in HETCOR spectra, a proton NMR spectrum is plotted on one axis and the $\text{^13"C}$ NMR spectrum is plotted on the other.

The peaks show which $\text{H}$ is attached to each $\text{C}$.

Here is the HETCOR spectrum of ethyl but-2-enoate.

(from www.chem.ucalgary.ca)

For example, Peak A indicates that the $\text{H}$ at 4.1 ppm is attached to the $\text{C}$ at 60 ppm.

This corresponds to the $\text{-OCH"_2"-}$ group of the ester.

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