# Why should the proton nuclei in different compounds behave differently in the NMR experiment ?

I can think of 1 example where different nuclei give rise to the the same chemical shift. If your compound has an active hydrogen (i.e. an alcoholic proton or an enolizable proton), it could be replaced by the deuterium isotope, $D$. This hydrogen will no longer appear in the proton NMR spectrum (because it is no longer a proton nucleus). It should appear in the corresponding deuterium NMR spectrum at the same chemical shift. Such labelling studies are relatively easy to perform, especially as deuterium, as heavy water, is dirt cheap.