How do chemists make epoxides?

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How do chemists make epoxides?

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Answer 1 · 2017-07-07T07:45:18

They use $meta-chloroperoxybenzoic acid$ $"meta-chloroperoxybenzoic acid"$

Explanation:

And thus the basic reaction is............

$olefin M C P B A - --- \to epoxide.....$ $"olefin "stackrel(MCPBA)rarr" epoxide....."$

And this is a powerful organic reaction, in that you can (potentially) make 2 chiral centres from an olefin, i.e. from $R_{1} R_{2} C = C R_{3} R_{4}$ $R_1R_2C=CR_3R_4$ to give $R_{1} R_{2} (H O) C - C R_{3} R_{4} (O H)$ $R_1R_2(HO)C-CR_3R_4(OH)$ after the epoxide ring is oxidized up. Current methods of synthesis (e.g. $Sharpless peroxidation$ $"Sharpless peroxidation"$ ) are good enuff to accomplish this end.

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How do chemists make epoxides?

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