Question

How will you prepare propanamine from methyl chloride using suitable reactions?

Answer 1

How about the sequence below?

Explanation:

1. Convert to a Grignard reagent

`"CH"_3"Br" stackrelcolor(blue)("dry ether"color(white)(m))(→) "CH"_3"MgBr"`

2. React with ethylene oxide

`"CH"_3"MgBr" stackrelcolor(blue)("1. ethylene oxide"color(white)(m))(stackrelcolor(blue)("2. H"^+color(white)(mmmmmml))(→)) "CH"_3"CH"_2"CH"_2"OH"`

3. Convert to the chloride

`"CH"_3"CH"_2"CH"_2"OH" stackrelcolor(blue)("PCl"_3color(white)(m))→ "CH"_3"CH"_2"CH"_2"Cl"`

4. React with `"NH"_3`

`"CH"_3"CH"_2"CH"_2"Cl" stackrelcolor(blue)("NH"_3color(white)(m))(→) "CH"_3"CH"_2"CH"_2"NH"_2`